Nitric oxide (NO, not nitrous oxide N2O the laughing gas) is a powerful and critically important molecule produced throughout our bodies. It acts as an antiviral and antimicrobial agent, creating super oxides that kill infection.  NO is also a vasodilator that helps expand the blood vessels in the lungs to improve oxygenation.  It also acts as an anti-thrombotic agent, preventing clotting and platelet activation in the body and during open-heart surgery.  NO is also an important messaging molecule that can regulate brain function by changing blood flow and oxygenation. 

NOTA is focused on delivering novel, low-cost, on-demand NO delivery systems for both the hospital and in-home use that augment the body's product on NO in treating and preventing a wide variety of life-threatening illnesses and conditions.  There are hundreds of ongoing clinical trials expanding the applications for this miracle molecule that are likely to reach the market in the next 5-years.

Nitric Oxide is widely found throughout nature in both the plant and animal kingdoms.  Human evolution has resulted in our body’s production of nitric oxide (NO) as a major component of our immune systems and as a messaging molecule throughout the body. Previously known by scientists as an air pollutant, NO’s production by a wide variety of cells in our bodies was only discovered in the early 1990’s with the discovery in human physiology leading to a Nobel Prize in 1998.

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Why does this small molecule play such a big and diverse role? NO’s broad range of applications can be attributed to the molecule’s high reactivity and transient nature which causes its direct action to be highly localized and yet can be stabilized as a nitrosothiol and thus able to be transported throughout the body.   As part of the immune systems it’s able to treat viral infection by inhibiting viral replication, attack microbes, affect vasodilation to decrease hypertension, and treat viral infection by inhibiting viral replication.