Nitric oxide is a potent vasodilator, making it ideal for the treatment of hypertension. Already, iNO is an approved treatment for neonates with pulmonary hypertension. Studies have shown that the administration of iNO during lung transplantation can prevent primary graft failure (PGF), improve oxygenation, and reduce pulmonary hypertension. Due to its antiseptic properties, iNO has been proposed as a treatment for chronic airway infections, especially in diseases like CF, sinusitis, tuberculosis, and COPD, where airway infections are common. When added to the sweep gas during open heart surgery (and other extracorporeal circulation [ECC] applications), it has been shown to prevent both thrombosis and systemic inflammatory response syndrome by preventing platelet and white blood cell activation. iNO is a highly effective treatment across a variety of applications.

However, NO tanks are expensive, costing up to $100 / hour of therapy. By comparison, NOTA’s NOGEN System can generate high levels of iNO (up to 500 ppm) for extended periods of time using an inexpensive chemical cartridge. NO generation is regulated by simply varying the current and voltage applied and the system is controlled by multiple in-line sensors. It is an ideal solution for the hospital setting where high concentrations and long-term therapy are required, without breaking the bank.

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Products are for investigational use only and are not yet commercially available