Therapeutic use of gas phase NO has several important applications in medicine and NOTA is working on new technologies to produce gas phase nitric oxide for these biomedical applications.
Since its first application more than 20 years ago, inhaled nitric oxide (INO) has become a mainstay of intensive care for lung failure patients.
As a pulmonary vasodilator, INO is essential in neonatology, lung transplantation, and pulmonary hypertension.
As an inhaled antiseptic agent, NO has been proposed in the treatment of chronic airway infections that occur in cystic fibrosis, sinusitis, and tuberculosis.
NO added to the sweep gas in extracorporeal circulation (ECC) (e.g. during open heart surgery, etc.) prevents activation of platelets (preventing thrombosis) and white blood cells (preventing systemic inflammatory response syndrome (SIRS)).
At present, INO is expensive to deploy in the healthcare setting. High cost is related to the long-term instability of NO within gas cylinders, which can generate low levels of toxic nitrogen dioxide (NO2) over time via a disproportionation reaction. This requires use of lower gas phase NO concentrations in the storage cylinders (800 ppm), necessitating very frequent changes in the gas tanks for clinical application. NOTA Laboratories is pursuing two completely new, much lower cost and highly portable methods developed at the University of Michigan to generate gas phase NO for biomedical applications.
NOTA's NOGEN solution employs electrochemical (E-chem) reaction technology to generate nitric oxide on demand. E-chem NO generation is simple, controllable, compact, and inexpensive. NO gas generation is controlled in the NOGEN system by modulating voltage and current through NOTA's self-contained proprietary consumables. The generated NO gas can be fed into a recipient air stream for medical applications over extended time intervals, and is ideal for use in the hospital setting.
NOTA's LANOR solution employs photochemical reaction technology to generate nitric oxide on demand. NO gas generation is controlled in the LANOR system by modulating an LED light source. NOTA's new photochemical NO generator is quite compact and is ideal for home use, especially for management of cystic fibrosis and other disorders in which chronic lung infections are prevalent.